Tag Archives: Personalized Cancer Medicine Initiative

University of Washington #5 Cancer Hospital and More Genotyping Patients by Vanderbilt

A little more about cancer research and treatment….

Good news for us closer to home is that our own University of Washington Medical Center is # 5 on the leading list of cancer hospitals in the nation, according to US News and World Reports.

http://health.usnews.com/best-hospitals/rankings/cancer

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“Vanderbilt-Ingram Cancer Center (VICC) has launched its new Personalized Cancer Medicine Initiative, becoming the first cancer center in the Southeast and one of the first in the nation to offer cancer patients routine “genotyping” of their tumors at the DNA level….”

Meaning patients will receive personalized treatments based on their own body changes pushing the cancer growth.

…”Vanderbilt is further leading the nation in personalizing medicine by leveraging its sophisticated Electronic Medical Record (EMR) to use the genotype information in point-of-care decision-making.
“The EMR for each patient is automatically updated to contain the latest genome-based treatment information, so that all healthcare providers at Vanderbilt caring for the patient are fully informed and guided by the latest decision support on these advanced therapies,” said Dan Masys, M.D., chair of the Department of Biomedical Informatics.

“We know that genetic differences in humans at the molecular level not only contribute to the disease process, but can also significantly impact an individual’s ability to respond optimally to drug therapy,” said Jeff Balser, M.D., Ph.D., vice chancellor for Health Affairs and dean of the School of Medicine. “…Project, with highly personalized therapy for our patients.”

Vanderbilt’s Personalized Cancer Medicine Program is led by William Pao, M.D., Ph.D., Ingram Associate Professor of Cancer Research and an expert in lung cancer….”“…
“The Personalized Cancer Medicine Initiative is our commitment to providing the most cutting-edge treatment for our patients,” said Jennifer Pietenpol, Ph.D., director of Vanderbilt-Ingram and B.F. Byrd Professor of Oncology.
Jeffrey Sosman, M.D., professor of Medicine, noted that having the genotype information is also important to help patients avoid the side effects of traditional chemotherapy.

“We are starting to understand how each patient’s tumor may have specific mutations that cause the cancer, but some of those mutations may also make the cancer vulnerable to specific therapy,” said Sosman, who directs the center’s Melanoma Program. “Tumor genotyping allows us to personalize our approach. If a tumor is likely to respond to a targeted therapy then we can avoid the side effects of traditional chemotherapy.”

http://www.vicc.org/news/2010/08/personalized-cancer-therapy/

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Following are portions of a letter written by a woman to her parents during a time when her husband was dying of pancreatic cancer far off in another state – with her permission.

She once told me the timed painkillers he had available didn’t stop the pain for long and he would scream out to her with the pain and beg her to give him another shot early.

A concern of the hospital seemed to be that he would become addicted to the drugs.
I wondered then, as now – what different would it make if he became addicted to pain medications?
He was dying.

The good news about Vanderbilt’s Personalized Cancer Medicine Initiative is one more step in the battle against cancer.

‘Dated Monday, Nov 2 -87.
Dear Mom & Dad,

Received the money you sent me…thank you.
It helped a lot because his drugs he has to have are very costly.
Just his filled morphine shots I give him are $163.00 every two weeks, not counting his other medicine.
This is mixed with cocaine.

Brought him home Sat.
Got here about 1:30pm and so thankful to be home again.

The nerve blocks he went through have deadened many of his nerve endings leading to his cancer.
He knows he is dying.
His mind is still very alert.
Thank God.
He told the Dr while I was out of the room that he was afraid of dying.
God what suffering.

He is in God’s hands.
He is humble & has prayed so hard for God to take him.
His spirit will one day go back to the Lord who gave it & then his struggle & his pain will be over.
Cancer is a slow & painful death.

I wonder sometimes why humans have to suffer so much. There is no answer of course.

I’ll never forget the beautiful people at the hospital who gave me their support & hands & hearts that reached out to us, & before I left the hospital, I went around & thanked them all for giving me so much when God knows I needed it.

Two wonderful & beautiful Drs -Dr Stewart & Dr Wright, they cared too, what we are facing.

They are frustrated because they can’t stop this cancer.
There is no form of x-rays that will show the kind of cancer Kenneth has in the early stages, only after it’s too late.

They became Dr’s to help heal their patients & in Kenneth’s case, it’s too late but they both did everything medically possible to ease him.

They are both so kind.
They wished they could tell me that it wasn’t too late.

Both of them would meet me in the hallway & be on the way to surgery but they always took the time to stop & take my hand & talk to me.

Thank God, for the wonderful & beautiful people left in this world.
There will always be a dawn because of the beauty of their souls & it rubbed off on me.

I’ll never forget any of them. Everyone at the hospital knew me & put their arm around me & asked how I was; no matter where I was in the hospital, so many people came over to me.
God Bless them all.

I know God has a special place for them & I have in my heart.

Don’t worry about me, I’m all right.

God Bless my two parents that I so dearly love. I keep you close to my heart & the miles apart make no difference.
With lots of love, Karen”

More later… Sharon O’Hara

Vanderbilt Takes Cancer Personally? Me too.

Meet Molly, Cancer Survivor.

Between Cancers
Resolute Molly

Molly is my wonderful re-homed girl and my fourth dog to get cancer in ten years. The only difference is she is still alive. Molly recently had a second cancer surgery and is almost healed.
Most of you already know more than you ever wanted to know about cancer, many of you have have lost loved ones to it. The faces of cancer in my family pale compared to most of you, but let me show you a few glimpses and faces of cancer in my family.

You are welcome to share a cancer photo here with us. Send it to me and I’ll add it here with mine.

Fresh From aDip in Smelly Pond
Hold Still, Ashley, We Will Cool You Down-fresh swim from smelly pond.
Annie Cut Her Baby Teeth on that Bench
Annie - A Favorite Bench
All 164 lbs of him
Mr G''s Buddy, my Mom
Mr Green standing, Annie behind, their Mom Sonja and my mom.

A few years later, June 6, 2008 my mom died from Pancreatic cancer… twelve years earlier my dad died of  Prostate cancer.

Cancer, cancer, go away. Don't come back any day.
Molly, Moving Easy at Home and Healing
A Good Healing
Cancer Caused Stitches, a second time around.

Molly, another look of cancer

A new bamboo shoot emerges
What does a bamboo shoot from a seemingly dead bamboo plant and cancer have in common? Survivors and dedicated researchers.
Puppies for All Time
The Kids at Rest
The Queen Surveys Her World
Sonja Waits for Her Ride
Queen Sonja, Mr. Green and Ms. Annie
Chuck returns Queen Sonja, Mr. Green and Annie ashes home to Ivy St.

The following story is verbatim so that nothing is lost in the telling. Vanderbilt takes cancer personally. Yes.

“Vanderbilt takes cancer personally.

That’s what the dominant Page One headline in today’s Tennessean says. It’s a play on words because the story is about Vanderbilt’s newly announced Personalized Cancer Medicine Initiative. (You can read more in the Vanderbilt-Ingram Cancer Center’s News Center).

But it’s also true in its most literal sense. The nurse who takes calls about this new initiative in the morning and then goes to her own chemotherapy appointment in the afternoon takes it personally. The physician-scientist who can share with his lung cancer patients his own experience with lymphoma takes it personally. The breast cancer survivor whose good friend is now in treatment and who read about this initiative on VICC’s Facebook page this morning takes it personally. The 1 in 2 men and 1 in 3 women among us who will face a cancer diagnosis, well, they have or will take it very personally.

As someone who has been an observer of cancer science for more than 15 years, I can tell you that no one takes this disease more personally than the investigators at the Vanderbilt-Ingram Cancer Center.

For months, Dr. William Pao, who directs the initiative, and his colleagues have focused on every detail, making sure the science was exactly right and the process of delivering on the promise of this discovery could go as smoothly as possible. Much time and energy has been spent in getting the announcement just right and making sure folks who might get questions from patients and families know what this means (and importantly what it doesn’t mean).

Whatever you take away from the coverage of this announcement, please know this. It’s a big deal, one in which everyone at Vanderbilt can and should take pride. No, we didn’t cure cancer this week. But we did demonstrate a leadership role in what many predict will be a sea change in how we diagnose and treat our patients, not only with cancer but with myriad other diseases as well.

So feel free to take it personally. I know I do.”

More later… Sharon O’Hara