Adrian, along with teammates Nicholas Thoman, Mark Gangloff and Michael Phelps, finished in a time of 3 minutes, 32.06 seconds, holding off Australia in 3:32.26. Germany won bronze.
Adrian found himself trailing the Japanese, who lead from the start, after diving in on the final leg. Adrian had a 50-meter split of 21.78 and touched the wall in a personal split of 47.64 as he blew past Shogo Hihara to claim the gold.
The US won 29 medals, 16 of them golds.